We are sorry for the inconvenience introduced by the SEA server blocked out by the safety system in our university. Now, SEA can be accessed through this indirect way, but all the functions and data access still need to wait for the recovery of the MySQL backend.
Super-Enhancer Archive is a web based comprehensive resource focuses on the collection, storage and online analysis of super-enhancers.
Our mission is to provide a curated set of information datasets for super-enhancers and tools in mutiple genomes, to support and
promote research in this area. Especially, we provide a genome-scale landscape to show super-enhancer information in a scalable and
Currently, Super-Enhancer Archive consists of super-enhancers in Human, Mouse and two key model organisms,including 75, 439 human
super-enhancers, 5, 879 mouse super-enhancers, 1, 774 D. melanogaster super-enhancers and 904 C. elegans super-enhancers respectively.
Super-Enhancer Archive supports analysis and chart view of these datasets, download for further analysis and can be even easily
visualized in the genome browser (SEA-Browser).
Further information of citation, updates and statistics are available in this page.
This site is updating regularly.
Super-enhancers are genome regions that are large clusters of transcriptional enhancers and drive expression of genes that define cell
identity. The term “super-enhancer” was motioned for the first time by Chen et al. in 2004 (Chen, Yao et al. 2004). They are identified
in large-scale by Richard A. Young and his colleagues in 2013 (Chapuy, McKeown et al. 2013, Hnisz, Abraham et al. 2013). It has been
reported that super-enhancers differ from typical enhancers in size, transcription factor density and content, and the ability to activate
transcription (Chapuy, McKeown et al. 2013). And Super-enhancers are regarded as the regulators of cell identity, ESC state
maintenance, and tumor pathogenesis.
For more information about super-enhancers, please go to the Documentation page in which the studies about super-enhancers are subtotaled.
(Hnisz, D., Abraham, B.J., Lee, T.I., Lau, A., Saint-Andre, V., Sigova, A.A., Hoke, H.A. and Young, R.A. (2013) Super-enhancers in the control of cell identity and disease. Cell, 155, 934-947.)
New - Super-Enhancer Archive is nearly the first integrated and interactive database of super-enhancers up to now as we know.
Comprehensive - It contains the super-enhancers identified in different cell/tissue types of multiple model species (Human, Mouse, Drosophila melanogaster, and Caenorhabditis elegans).
Convenient - It is convenient for biologists to query super-enhancer and its' related information of interested topics.
Functional - Function annotation could be done by integrated online analysis tools (SEA-Browser, TFBS enrichment, H3K27ac enrichment and GREAT).
Super-Enhancers have crucial functions in genome, just like the lighthouse illuminating the road ahead, they drive cell-type-specific extremely high expression of genes that define cell identity in development and disease.